Immunologic and molecular biologic studies of prion proteins in bovine spongiform encephalopathy.

@article{Prusiner1993ImmunologicAM,
  title={Immunologic and molecular biologic studies of prion proteins in bovine spongiform encephalopathy.},
  author={Stanley B Prusiner and M. F{\"u}zi and M. A. Scott and D Serban and Hana Serban and Albert Taraboulos and Jean Marc Gabriel and Gerald A. H. Wells and John W. Wilesmith and Ray Bradley},
  journal={The Journal of infectious diseases},
  year={1993},
  volume={167 3},
  pages={602-13}
}
Bovine spongiform encephalopathy (BSE) is a transmissible neurodegenerative disease. Six brain regions from 11 cattle were examined for the presence of the abnormal isoform of the prion protein (PrPBSE). The highest concentrations of PrPBSE were found in the brain stem, where the greatest degree of spongiform change was observed. Molecular cloning of the bovine PrP gene showed that it encodes a protein of 256 or 264 amino acids with five or six Gly:Pro-rich octarepeats, respectively, in… CONTINUE READING