Immunologic and functional evidence for anti-Siglec-9 autoantibodies in intravenous immunoglobulin preparations.

@article{Gunten2006ImmunologicAF,
  title={Immunologic and functional evidence for anti-Siglec-9 autoantibodies in intravenous immunoglobulin preparations.},
  author={Stephan von Gunten and Alexander Schaub and Monique Vogel and Beda M. Stadler and Sylvia Miescher and Hans-Uwe Simon},
  journal={Blood},
  year={2006},
  volume={108 13},
  pages={
          4255-9
        }
}
Human intravenous immunoglobulin (IVIg) preparations are increasingly used for the treatment of autoimmune diseases. Earlier work demonstrated the presence of autoantibodies against Fas in IVIg, suggesting that IVIg might be able to induce caspase-dependent cell death in Fas-sensitive cells. In this study, we demonstrate that sialic acid-binding Ig-like lectin 9 (Siglec) represents a surface molecule on neutrophils that is activated by IVIg, resulting in caspase-dependent and caspase… CONTINUE READING

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