Immunologic and clinical observations of granulocyte-specific antinuclear antibodies.

@article{Svec1969ImmunologicAC,
  title={Immunologic and clinical observations of granulocyte-specific antinuclear antibodies.},
  author={Kathryn H. Svec},
  journal={Arthritis and rheumatism},
  year={1969},
  volume={12 3},
  pages={
          165-72
        }
}
  • K. H. Svec
  • Published 1 June 1969
  • Medicine
  • Arthritis and rheumatism
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9 Citations
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9 Citations

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Antineutrophil cytoplasmic antibodies in rheumatoid arthritis. Characterization and clinical correlations.
TLDR
ANCA in RA patients are directed toward diverse cytoplasmic antigens of the neutrophil, in particular, LF and other, not yet fully characterized polypeptides.
Antineutrophil cytoplasmic antibodies: a still-growing class of autoantibodies in inflammatory disorders.
Substrate specificity of antinuclear antibodies in scleroderma.
TLDR
Titans of sera reacting positively on 2 or 3 substrates were mostly in agreement, although some sera both in systemic scleroderma and SLE showed higher titers on monkey esophagus, and the IF pattern was usually the same regardless of the substrate.
Serum antibody in rheumatoid arthritis reactive with a cell-associated antigen. Demonstration by precipitation and immunofluorescence.
TLDR
Indirect immunofluorescence with Wil2 cells as substrate was used to demonstrate RAP and to determine morphologically the nature of the reactive cellular antigen, and IF was employed to demonstrate that RAP is immunoglobulin belonging to IgG and IgM classes and not to IgA or IgD.
Antinuclear antibodies. I. Patterns of nuclear immunofluorescence.
TLDR
Fifteen separate and distinct nuclear immun ofluorescent patterns have been identified by indirect immunofluorescence employing human spleen touch imprints as substrate, and these patterns have to be differentiated from those specifically associated with certain diseases.
Immunological Aspects of Skin Diseases
[Evaluation of two different antigen preparations in the fluorescent antibody test for antinuclear antibodies (ANA). A comparison between two laboratories].
TLDR
Two different antigen preparations of human origin (sectioned thyroid cells and blood smears) were compared in the indirect immunofluorescence (IF) test for antinuclear antibodies (ANA) and all sera showing speckled staining with thyroid sections were negative with blood smear.
Epstein-Barr virus (herpes-type virus) antibodies in connective tissue diseases.
TLDR
Recognizing antibody activity not specific to EBV infection will be useful to workers employing these tests in future seroepidemiologic studies.
Diagnosis of lupus erythematosus and rheumatoid arthritis in children.

References

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Comprehensive outpatient care in rheumatoid arthritis. A controlled study.
TLDR
Patients with classical or definite rheumatoid arthritis by American Rheumatism Association (ARA) criteria, were randomly assigned to treatment and control groups in a study of effectiveness of multidisciplinary clinic and home care.
Two new antinuclear antibodies: their relationship to the homogeneous immunofluorescent pattern.
Age-related antinuclear factors: immunologic characteristics and associated clinical aspects.
The use of human spleen imprints for routine testing for serum antinuclear factors by immunofluorescence.
  • K. H. Svec
  • Medicine
    American journal of clinical pathology
  • 1967
Leucocyte-specific anti-nuclear factors in patients with felty's syndrome, rheumatoid arthritis, systemic lupus erythematosus and other diseases.
Reaction of antinuclear factors with polymorphonuclear leucocytes. 1. Absorption studies.
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  • 1966
ANTINUCLEAR FACTORS IN SYSTEMIC LUPUS ERYTHEMATOSUS AND RHEUMATOID ARTHRITIS.
Excerpt Discovery of the lupus erythematosus (LE) cell phenomenon in 1948 by Hargraves, Richmond, and Morton (1) was the first of a series of observations of what have proved to be immunologic phen...
AN ANTINUCLEAR FACTOR SPECIFIC FOR LEUCOCYTES.
EFFECT OF CELL CONCENTRATION ON THE METABOLISM OF NORMAL AND DIABETIC LEUCOCYTES IN VITRO.
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GAMMA-2, GAMMA-1A AND GAMMA-1M ANTINUCLEAR FACTORS IN HUMAN SERA.
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