Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients.

@article{Hodi2008ImmunologicAC,
  title={Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients.},
  author={Frank Stephen Hodi and Marcus O Butler and Darryl A Oble and Michael V. Seiden and Frank G. Haluska and Andrea Kruse and Suzanne Macrae and Marybeth Nelson and Christine M. Canning and Israel Lowy and Alan J Korman and David B. Lautz and Sara Russell and Michael Thomas Jaklitsch and Nikhil Himmatsinh Ramaiya and Teresa C. Chen and Donna S Neuberg and James P Allison and Martin C. Mihm and Glenn Dranoff},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 8},
  pages={3005-10}
}
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) functions as a negative regulator of endogenous and vaccine-induced antitumor immunity. The administration of fully human anti-CTLA-4 blocking monoclonal antibodies to advanced-cancer patients increases immune-mediated tumor destruction in some subjects. Nonetheless, patients that respond also frequently manifest serious inflammatory pathologies, raising the possibility that the therapeutic and toxic effects of CTLA-4 blockade might be linked… CONTINUE READING

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