Immunologic activation of hepatic macrophages in septic rats: a possible mechanism of sepsis-associated liver injury.

@article{Furutani1994ImmunologicAO,
  title={Immunologic activation of hepatic macrophages in septic rats: a possible mechanism of sepsis-associated liver injury.},
  author={Masanori Furutani and Shigeki Arii and Kazunobu Monden and Yuichi Adachi and Naomi Omichi Funaki and Hiroaki Higashitsuji and Satoshi Fujita and Masahiro Mise and Shigeru Ishiguro and Takashi Kitao},
  journal={The Journal of laboratory and clinical medicine},
  year={1994},
  volume={123 3},
  pages={430-6}
}
To investigate the pathogenesis of liver dysfunction accompanying intra-abdominal sepsis, we used rats with cecal ligation and punctures (CLP) and examined the expression of the inflammatory cytokines IL-1-alpha, IL-1-beta, and TNF-alpha, as well as the expression of a cell adhesion molecule, ICAM-1, in the liver. We also examined the expression of Ia… CONTINUE READING