Immunologic Effects of Metformin and Pioglitazone Treatment on Metabolic Syndrome and Multiple Sclerosis.

@article{Negrotto2016ImmunologicEO,
  title={Immunologic Effects of Metformin and Pioglitazone Treatment on Metabolic Syndrome and Multiple Sclerosis.},
  author={Laura Negrotto and Mauricio Franco Farez and Jorge Correale},
  journal={JAMA neurology},
  year={2016},
  volume={73 5},
  pages={
          520-8
        }
}
IMPORTANCE Metabolic syndrome (MetS) is thought to influence several autoimmune diseases, including multiple sclerosis (MS). Anti-inflammatory effects of treatments used for MetS, such as metformin hydrochloride and pioglitazone hydrochloride, have been demonstrated, although clinical evidence supporting use of these treatments in MS is lacking. OBJECTIVES To determine whether metformin and/or pioglitazone are associated with a reduction in disease activity as measured by brain magnetic… CONTINUE READING
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