Immunolocalization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies.

@article{Bleecker1999ImmunolocalizationOT,
  title={Immunolocalization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies.},
  author={Jan L. De Bleecker and Veronique I. Meire and Wim Declercq and Elisabeth H Van Aken},
  journal={Neuromuscular disorders : NMD},
  year={1999},
  volume={9 4},
  pages={239-46}
}
Adhesion molecule upregulation occurs in inflammatory myopathies, and is one of the myriad functions of tumor necrosis factor-alpha (TNF-alpha). TNF-alpha acts via two different receptors of 55 (TNF-R55) and 75 kD (TNF-R75). We immunolocalized TNF-alpha and its receptors in polymyositis, inclusion body myositis and dermatomyositis. In each myopathy, TNF-alpha was detected in macrophages, in myonuclei in regenerating muscle fibers, and freely dispersed in endomysial or perimysial connective… CONTINUE READING