Immunolocalization of the cellular prion protein in normal brain.

  title={Immunolocalization of the cellular prion protein in normal brain.},
  author={Kenneth L. Moya and Nicole Sal{\`e}s and Raymonde H{\"a}ssig and Christophe A Cr{\'e}minon and Jaques Grassi and Luigi Di Giamberardino},
  journal={Microscopy research and technique},
  volume={50 1},
We examined the localization of PrP(c) in normal brain using free-floating section immunohistochemistry and monclonal antibody 3F4. In the mature hamster and baboon brain, PrP(c) is localized to the neuropil with a synaptic distribution and the PrP(c) immunoreactivity is denser in regions known for ongoing plasticity. Cell bodies and major fiber tracts have little or no PrP(c) immunoreactivity. At the electron microscopic level, PrP(c) immunoreactivity decorates synaptic profiles, both pre- and… CONTINUE READING