Immunolocalization of cathepsin B in human glioma: implications for tumor invasion and angiogenesis.

  title={Immunolocalization of cathepsin B in human glioma: implications for tumor invasion and angiogenesis.},
  author={T. G. Mikkelsen and Pearlly Yan and Khang L Ho and Mansoureh Sameni and Bonnie F Sloane and Mark L. Rosenblum},
  journal={Journal of neurosurgery},
  volume={83 2},
The poor prognosis of patients with malignant gliomas is at least partially due to the invasive nature of these tumors. In this study, the authors investigated the possibility that the cysteine protease cathepsin B (CB) is a participant in the process of glial tumor cell invasion. To accomplish this, an immunohistochemical analysis was made of the localization of antibodies to CB in biopsies of five specimens of normal brain, 16 astrocytomas, 33 anaplastic astrocytomas, and 33 glioblastomas… CONTINUE READING


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