Immunolocalization of Zic2 expression in the developing mouse forebrain.

  title={Immunolocalization of Zic2 expression in the developing mouse forebrain.},
  author={Lucia Y. Brown and Andreas H. Kottmann and Stephen Brown},
  journal={Gene expression patterns : GEP},
  volume={3 3},
The Zic genes are a family of zinc finger transcription factors defined by their homology with the Drosophila gene, odd-paired (opa). Zic2 has a critical role in forebrain development, as is evidenced by the fact that, in both mice and humans, diminished expression results in the severe forebrain malformation known as holoprosencephaly. Published information indicates that Zic2 expression is most prominent in the dorsal neural tube/spinal cord and in the hindbrain; however, there is no… CONTINUE READING
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