Immunolocalisation of vascular endothelial growth factor (VEGF) in human neonatal growth plate cartilage.

@article{Horner1999ImmunolocalisationOV,
  title={Immunolocalisation of vascular endothelial growth factor (VEGF) in human neonatal growth plate cartilage.},
  author={Alan Horner and Nicholas Bishop and Sharyn Bord and Christine Beeton and Anthony W Kelsall and Nicholas Coleman and Juliet E Compston},
  journal={Journal of anatomy},
  year={1999},
  volume={194 ( Pt 4)},
  pages={519-24}
}
Angiogenesis is essential for the replacement of cartilage by bone during growth and repair. In order to obtain a better understanding of the mechanisms regulating vascular invasion at sites of endochondral ossification we have investigated the expression of the endothelial cell-specific mitogen, vascular endothelial growth factor (VEGF), by chondrocytes in human neonatal growth plates. VEGF was absent from chondrocytes in the resting zone and only weakly expressed by occasional chondrocytes in… CONTINUE READING