Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain.

  title={Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain.},
  author={Helen C Baxter and Weizhen Liu and Jean Lois Forster and Alastair Aitken and Janet R Fraser},
  volume={109 1},
The appearance of 14-3-3 proteins in the cerebrospinal fluid is characteristic of some neurodegenerative conditions which include sporadic Creutzfeldt-Jakob disease. Although 14-3-3 proteins are physiochemically well characterised and are known to be present in neuronal cells little is known of the neuroanatomical localisation of the individual isoforms. Using 14-3-3 isoform specific antibodies we have examined the distribution of the isoforms in normal murine brain and the changes observed… CONTINUE READING


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