Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor.

  title={Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor.},
  author={Ronald G. Wiley and T. N. Oeltmann and Douglas A. Lappi},
  journal={Brain research},
  volume={562 1},
192 IgG, a monoclonal antibody to the rat nerve growth factor (NGF) receptor, was disulfide-coupled to saporin, a ribosome-inactivating protein. Systemic injection of 192 IgG-saporin destroyed sympathetic postganglionic neurons and some sensory neurons. Injection of 192 IgG-saporin into the lateral ventricle destroyed cholinergic neurons of the basal forebrain. These results show that antineuronal immunotoxins are a powerful approach that may prove useful in a variety of neurobiological… CONTINUE READING
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