Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis.

@article{Zhang2017ImmunoinhibitoryCD,
  title={Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis.},
  author={Hui Zhang and Ryu Watanabe and Gerald J. Berry and Augusto Vaglio and Yaping Joyce Liao and Kenneth J. Warrington and J{\"o}rg J Goronzy and Cornelia M Weyand},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 6},
  pages={
          E970-E979
        }
}
Giant cell arteritis (GCA) causes autoimmune inflammation of the aorta and its large branches, resulting in aortic arch syndrome, blindness, and stroke. CD4+ T cells and macrophages form organized granulomatous lesions in the walls of affected arteries, destroy the tunica media, and induce ischemic organ damage through rapid intimal hyperplasia and luminal occlusion. Pathogenic mechanisms remain insufficiently understood; specifically, it is unknown whether the unopposed activation of the… CONTINUE READING
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