Immunohistology and immunocytology of human T-cell chimerism and graft-versus-host disease in SCID mice.

@article{HoffmannFezer1993ImmunohistologyAI,
  title={Immunohistology and immunocytology of human T-cell chimerism and graft-versus-host disease in SCID mice.},
  author={Gertrud Hoffmann-Fezer and Claudius Gall and U Zengerle and Birgitta Kranz and S{\"o}ren Thierfelder},
  journal={Blood},
  year={1993},
  volume={81 12},
  pages={3440-8}
}
Surprisingly little graft-versus-host disease (GVHD) has been observed in severe combined immunodeficient (SCID) mice injected intraperitoneally (IP) with human blood lymphocytes (hu-PBL-SCID), which raised the question as to whether GVHD in such a distant species is sporadic or suppressed because of immunologic reasons. After screening for blood T-cell chimerism, we hereby describe generalized lethal xenogeneic human GVHD in unconditioned SCID chimeras, which resembles GVHD in SCID mice… CONTINUE READING
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