Immunohistological study for estrogenic activities of nitrophenols in diesel exhaust particles

@article{Furuta2007ImmunohistologicalSF,
  title={Immunohistological study for estrogenic activities of nitrophenols in diesel exhaust particles},
  author={C. Furuta and Chunmei Li and S. Taneda and A. Suzuki and K. Kamata and G. Watanabe and K. Taya},
  journal={Endocrine},
  year={2007},
  volume={27},
  pages={33-36}
}
We recently isolated 3-methyl-4-nitrophenol (4-nitro-m-cresol; PNMC) and 4-nitro-3-phenylphenol (PNMPP) from diesel exhaust particles (DEP) and identified them as vasodilators and xenoestrogens. The estrogenic activity of PNMC and PNMPP was further examined by using immunohistochemical staining of proliferating cell nuclear antigen (PCNA) in uterine luminal epithelium of ovariectomized 25-d-old immature female rats injected with PNMC and PNMPP subcutaneously for 2 d. Significant increases were… Expand
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