Immunohistologic study of bone marrow involvement in B-chronic lymphocytic leukemia.

@article{Pizzolo1983ImmunohistologicSO,
  title={Immunohistologic study of bone marrow involvement in B-chronic lymphocytic leukemia.},
  author={Giovanni Pizzolo and Marco Chilosi and Achille Ambrosetti and Gianpietro Semenzato and Luciano Fiore-Donati and G Perona},
  journal={Blood},
  year={1983},
  volume={62 6},
  pages={1289-96}
}
Bone marrow trephine biopsies from 17 patients with B-chronic lymphocytic leukemia (B-CLL) were studied by immunohistologic techniques in order to investigate the cellular phenotypes of both neoplastic (B-lymphoid) and reactive (T-lymphoid) infiltrates. For this purpose, several heteroantisera and monoclonal antibodies against human Ig isotypes, HLA-DR antigens, and T-cell subpopulations were used in immunofluorescence. The findings were analyzed in relationship to the histologic pattern of… CONTINUE READING

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