Immunohistologic evaluation of invasion-associated proteases in breast carcinoma.

  title={Immunohistologic evaluation of invasion-associated proteases in breast carcinoma.},
  author={Daniel W. Visscher and Fazlul H. Sarkar and Patricia Lorusso and Wael Sakr and Soren Ottosen and Susan Mary Wykes and John D. Crissman},
  journal={Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc},
  volume={6 3},
Immunostaining of two invasion-associated proteolytic enzymes, cathepsin D (CD) and urokinase-type plasminogen activator (uPA), was assessed in cryostat sections of 86 stage-heterogeneous breast carcinomas using monoclonal antibodies. Most tumors displayed a focal and/or heterogeneous staining pattern. Overall, staining was more frequent in host-derived stromal and inflammatory cells (uPA 54%, CD 89%) than neoplastic epithelium per se (uPA 24%, CD 70%). Intense (i.e., 2+) stromal, but not… CONTINUE READING