Immunohistochemistry for hMLH1 and hMSH2: a practical test for DNA mismatch repair-deficient tumors.

@article{Marcus1999ImmunohistochemistryFH,
  title={Immunohistochemistry for hMLH1 and hMSH2: a practical test for DNA mismatch repair-deficient tumors.},
  author={Victoria A. Marcus and Lisa Madlensky and Robert Gryfe and Han-seong Kim and Kanji So and Anna L. Millar and Larissa K. F. Temple and Eugene T K Hsieh and Tadaaki Hiruki and Steven A Narod and Bharati Bapat and Steven Gallinger and Mark Redston},
  journal={The American journal of surgical pathology},
  year={1999},
  volume={23 10},
  pages={1248-55}
}
Inactivation of deoxyribonucleic acid (DNA) mismatch repair genes, most commonly human mutL homologue 1 (hMLH1) or human mutS homologue 2 (hMSH2), is a recently described alternate pathway in cancer development and progression. The resulting genetic instability is characterized by widespread somatic mutations in tumor DNA, and is termed high-frequency microsatellite instability (MSI-H). Although described in a variety of tumors, mismatch repair deficiency has been studied predominantly in… CONTINUE READING