Immunohistochemistry for ERG expression as a surrogate for TMPRSS2-ERG fusion detection in prostatic adenocarcinomas.

  title={Immunohistochemistry for ERG expression as a surrogate for TMPRSS2-ERG fusion detection in prostatic adenocarcinomas.},
  author={Alcides M. Chaux and Roula Albadine and Antoun Toubaji and Jessica L. Hicks and Alan K Meeker and Elizabeth A. Platz and Angelo M De Marzo and George J Netto},
  journal={The American journal of surgical pathology},
  volume={35 7},
BACKGROUND TMPRSS2-ERG fusions have been identified in about one-half of all prostatic adenocarcinomas (PCas). Fluorescence in situ hybridization (FISH) and reverse transcription polymerase chain reaction have been the most commonly used techniques in this setting. The aim of this study was to evaluate the utility of ERG immunoexpression as a surrogate for TMPRSS2-ERG fusion in a large series of PCa cases. MATERIALS AND METHODS Four hundred twenty-seven radical retropubic prostatectomy tissue… CONTINUE READING


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