Immunohistochemistry for ERG expression as a surrogate for TMPRSS2-ERG fusion detection in prostatic adenocarcinomas.

@article{Chaux2011ImmunohistochemistryFE,
  title={Immunohistochemistry for ERG expression as a surrogate for TMPRSS2-ERG fusion detection in prostatic adenocarcinomas.},
  author={Alcides M. Chaux and Roula Albadine and Antoun Toubaji and Jessica L. Hicks and Alan K Meeker and Elizabeth A. Platz and Angelo M De Marzo and George J Netto},
  journal={The American journal of surgical pathology},
  year={2011},
  volume={35 7},
  pages={1014-20}
}
BACKGROUND TMPRSS2-ERG fusions have been identified in about one-half of all prostatic adenocarcinomas (PCas). Fluorescence in situ hybridization (FISH) and reverse transcription polymerase chain reaction have been the most commonly used techniques in this setting. The aim of this study was to evaluate the utility of ERG immunoexpression as a surrogate for TMPRSS2-ERG fusion in a large series of PCa cases. MATERIALS AND METHODS Four hundred twenty-seven radical retropubic prostatectomy tissue… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

Modification of the association between obesity and lethal prostate cancer by TMPRSS2:ERG.

Journal of the National Cancer Institute • 2013
View 14 Excerpts
Highly Influenced

The TMPRSS2:ERG rearrangement, ERG expression, and prostate cancer outcomes: a cohort study and meta-analysis.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2012
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 46 references

ETS gene fusions in prostate cancer

Nature Reviews Urology • 2009
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…