Immunohistochemically detected tumor cells in the sentinel lymph nodes of patients with breast carcinoma: biologic metastasis or procedural artifact?

@article{Moore2004ImmunohistochemicallyDT,
  title={Immunohistochemically detected tumor cells in the sentinel lymph nodes of patients with breast carcinoma: biologic metastasis or procedural artifact?},
  author={Katrina H Moore and Howard T. Thaler and Lee Khing Tan and Patrick Ivan Borgen and Hiram S. Cody},
  journal={Cancer},
  year={2004},
  volume={100 5},
  pages={929-34}
}
BACKGROUND Sentinel lymph node (SLN) biopsy is a new standard of care for patients with breast carcinoma, and allows enhanced pathologic analysis with serial sections and immunohistochemical (IHC) staining for cytokeratins to be performed on a routine basis. However, the significance of SLN micrometastases detected only by IHC is uncertain. Are these tumor cells truly markers of metastatic potential, or simply evidence of passive displacement by preoperative instrumentation of the tumor site… CONTINUE READING
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