Immunohistochemical visualisation of cathepsin-D expression in breast cancer.

BACKGROUND Cathepsin D (Cath-D), a lysosomal protease, is considered to be involved in the breakdown of the extracellular matrix during the process of tumour metastasis. Its expression in breast cancer in association with known factors of prognosis was investigated in this study. MATERIAL AND METHODS 120 breast cancer tumours were analysed… CONTINUE READING