Immunohistochemical study on the distribution of insulin-like growth factor I (IGF-I) receptor in the central nervous system of SOD1(G93A) mutant transgenic mice.

@article{Chung2003ImmunohistochemicalSO,
  title={Immunohistochemical study on the distribution of insulin-like growth factor I (IGF-I) receptor in the central nervous system of SOD1(G93A) mutant transgenic mice.},
  author={Yoon Chung and Kyeung Min Joo and Chung Min Shin and Yun Jung Lee and Dong Hoon Shin and Kyung Hoon Lee and Choong Ik Cha},
  journal={Brain research},
  year={2003},
  volume={994 2},
  pages={253-9}
}
In the present study, we used the SOD1(G93A) mutant transgenic mice as an in vivo model of ALS and performed immunohistochemical studies to investigate the changes of insulin-like growth factor I (IGF-I) receptor in the central nervous system. IGF-I receptor-immunoreactive astrocytes were detected in the spinal cord, brainstem, central gray and cerebellar nuclei of SOD1(G93A) transgenic mice. In contrast to transgenic mice, no IGF-I receptor-immunoreactive astrocytes were observed in any brain… CONTINUE READING
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