Immunohistochemical study of the expression of a Mr 34,000 human epithelium-specific surface glycoprotein in normal and malignant tissues.

@article{Momburg1987ImmunohistochemicalSO,
  title={Immunohistochemical study of the expression of a Mr 34,000 human epithelium-specific surface glycoprotein in normal and malignant tissues.},
  author={Frank Momburg and Gerhard Moldenhauer and G{\"u}nter J. H{\"a}mmerling and Peter L Moeller},
  journal={Cancer research},
  year={1987},
  volume={47 11},
  pages={2883-91}
}
Monoclonal antibody HEA125 was used to study the tissue distribution of an epithelial cell surface glycoprotein of Mr 34,000 (Egp34). A large panel of normal and neoplastic tissues was examined for immunoreactivity with HEA125 by means of a sensitive immunoperoxidase technique. HEA125 labeled most epithelial cell types throughout the body but did not label any nonepithelial tissue. Major exceptions were epidermal keratinocytes, gastric parietal cells, hepatocytes, thymic cortical epithelial… CONTINUE READING

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The majority of squamous cell carcinomas were less strongly labeled than adenocarcinomas ; keratinizing areas of the tumor masses were negative .
The majority of squamous cell carcinomas were less strongly labeled than adenocarcinomas ; keratinizing areas of the tumor masses were negative .
The majority of squamous cell carcinomas were less strongly labeled than adenocarcinomas ; keratinizing areas of the tumor masses were negative .
The majority of squamous cell carcinomas were less strongly labeled than adenocarcinomas ; keratinizing areas of the tumor masses were negative .
Immunohistochemical study of the expression of a Mr 34,000 human epithelium - specific surface glycoprotein in normal and malignant tissues .
Immunohistochemical study of the expression of a Mr 34,000 human epithelium - specific surface glycoprotein in normal and malignant tissues .
keratinocyteAnatomic structure is physical part ofEpidermis
Major exceptions were epidermal keratinocytes , gastric parietal cells , hepatocytes , thymic cortical epithelial , and myoepithelial cells .
Egp34 was found to be absent from sarcomas , lymphomas , melanomas , and neurogenic tumors .
Egp34 was found to be absent from sarcomas , lymphomas , melanomas , and neurogenic tumors .
Egp34 was found to be absent from sarcomas , lymphomas , melanomas , and neurogenic tumors .
LymphomaNo subtypeSarcoma
Egp34 was found to be absent from sarcomas , lymphomas , melanomas , and neurogenic tumors .
SarcomaNo subtypeLymphoma
Egp34 was found to be absent from sarcomas , lymphomas , melanomas , and neurogenic tumors .
Egp34 was found to be absent from sarcomas , lymphomas , melanomas , and neurogenic tumors .
melanomaNo subtypeSarcoma
Egp34 was found to be absent from sarcomas , lymphomas , melanomas , and neurogenic tumors .
SarcomaNo subtypemelanoma
Egp34 was found to be absent from sarcomas , lymphomas , melanomas , and neurogenic tumors .
Germ cell tumors and mesotheliomas of epithelioid type focally expressed the antigen .
The majority of squamous cell carcinomas were less strongly labeled than adenocarcinomas ; keratinizing areas of the tumor masses were negative .
The majority of squamous cell carcinomas were less strongly labeled than adenocarcinomas ; keratinizing areas of the tumor masses were negative .
Egp34 was found to be absent from sarcomas , lymphomas , melanomas , and neurogenic tumors .
Egp34 was found to be absent from sarcomas , lymphomas , melanomas , and neurogenic tumors .
Germ cell tumors and mesotheliomas of epithelioid type focally expressed the antigen .
Egp34 was found to be absent from sarcomas , lymphomas , melanomas , and neurogenic tumors .
Immunohistochemical study of the expression of a Mr 34,000 human epithelium - specific surface glycoprotein in normal and malignant tissues .
Immunohistochemical study of the expression of a Mr 34,000 human epithelium - specific surface glycoprotein in normal and malignant tissues .
SarcomaNo subtypeLymphoma
Egp34 was found to be absent from sarcomas , lymphomas , melanomas , and neurogenic tumors .
Egp34 was found to be absent from sarcomas , lymphomas , melanomas , and neurogenic tumors .
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