Immunohistochemical study of neurons containing corticotropin-releasing factor in Alzheimer's disease.

@article{Powers1987ImmunohistochemicalSO,
  title={Immunohistochemical study of neurons containing corticotropin-releasing factor in Alzheimer's disease.},
  author={Robert E. Powers and Lary C Walker and E B Desouza and Wylie W. Vale and Robert G. Struble and Peter J. Whitehouse and Donald L. Price},
  journal={Synapse},
  year={1987},
  volume={1 5},
  pages={405-10}
}
In the brains of controls and individuals with Alzheimer's disease (AD), antisera to corticotropin-releasing factor (CRF) were used to immunostain neurons and their processes. In AD, we identified abnormal CRF-immunoreactive axons as well as neurites associated with deposits of amyloid in brain regions showing senile plaques. The number of immunoreactive fibers was decreased in individuals with AD. In contrast, CRF immunoreactivity was markedly increased in some neurons located within the… CONTINUE READING