Immunohistochemical study of netrin-1 in the spinal cord with rat experimental autoimmune encephalomyelitis.

  title={Immunohistochemical study of netrin-1 in the spinal cord with rat experimental autoimmune encephalomyelitis.},
  author={Changjong Moon and Meejung Ahn and Chanwoo Jeong and Heechul Kim and Taekyun Shin},
  journal={Immunological investigations},
  volume={40 2},
To investigate whether netrin-1 is involved in autoimmune injury of the central nervous system, the expression of netrin-1 protein was analyzed in the spinal cord of Lewis rats with experimental autoimmune encephalomyelitis (EAE). Western blot analysis revealed significantly increased content of netrin-1 in the spinal cords of rats at the peak stage of EAE, as compared with the levels in normal control animals (p < 0.01). Immunohistochemistry detected the netrin-1 protein in neurons… CONTINUE READING


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