Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain.

@article{Takedo1996ImmunohistochemicalSO,
  title={Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain.},
  author={A Takedo and Takeshi Yasuda and Toshio Miyata and Ken Mizuno and Meng-fei Li and Shigeto Yoneyama and Katsunori Horie and Kiyoshi Maeda and Gen Sobue},
  journal={Neuroscience letters},
  year={1996},
  volume={221 1},
  pages={17-20}
}
Advanced glycation end products (AGEs) in the brain were immunohistochemically examined in Alzheimer's disease (AD) and aging using anti-AGE antibody recognizing mainly carboxymethyllysine. AGE positive staining diffusely located in the neuronal perikarya of hippocampus and parahippocampus in AD and aged brains without dementia, but not in young brains less than 17 years of age. Extra-neuroperikaryal AGE deposits were also detected in the neuropil of AD and aged brains. The extra… CONTINUE READING