Immunohistochemical study of HLA-G expression in lung transplant recipients.

  title={Immunohistochemical study of HLA-G expression in lung transplant recipients.},
  author={Olivier Brugi{\`e}re and Gabriel Thabut and Marina Pretolani and Ir{\`e}ne Krawice-Radanne and Christina Dill and A Herbreteau and Isabelle Poras and Philippe Moreau and Magali Colombat and Claire Danel and Monique Dehoux and Michel Fournier and Edgardo D. Carosella and Nathalie Rouas-Freiss},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  volume={9 6},
Human leukocyte antigen-G (HLA-G), a nonclassical HLA class I protein, promotes immune tolerance of solid-organ allografts, yet its role in lung transplantation (LTx) is unknown. We examined the expression of HLA-G in lung allografts through immunohistochemistry by a cross-sectional study of 64 LTx recipients, classified into four groups (stable patients, acute rejection [AR], bronchiolitis obliterans syndrome [BOS] and symptomatic viral shedders). A marked expression of HLA-G in bronchial… CONTINUE READING


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