Immunohistochemical study of 40 cases of longitudinal melanonychia.

  title={Immunohistochemical study of 40 cases of longitudinal melanonychia.},
  author={Anne Theunis and Bertrand Richert and U. G. W. Sass and Nadine Lateur and François Sal{\`e}s and J. Andr{\'e}},
  journal={The American Journal of dermatopathology},
  volume={33 1},
The etiology of longitudinal melanonychia (LM) is difficult to establish by clinical and dermoscopic examinations alone. Microscopic examination of the nail matrix remains crucial. Two groups of LM may be identified: melanocytic activation (melanic pigmentation of the matrix epithelium without any increase in the density of melanocytes) and melanocytic proliferation (lentigo, nevus, or melanoma). The histological examination is challenging, and immunohistochemical investigations can be helpful… CONTINUE READING

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