Immunohistochemical staining for Ki-67 antigen, carcinoembryonic antigen, and p53 in the differential diagnosis of glandular lesions of the cervix.

@article{Cina1997ImmunohistochemicalSF,
  title={Immunohistochemical staining for Ki-67 antigen, carcinoembryonic antigen, and p53 in the differential diagnosis of glandular lesions of the cervix.},
  author={Stephen J Cina and Mary S Richardson and R. Marshall Austin and Robert J. Kurman},
  journal={Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc},
  year={1997},
  volume={10 3},
  pages={176-80}
}
Cytoplasmic carcinoembryonic antigen (CEA) positivity assists in the distinction of benign and malignant glandular lesions of the cervix, but some cases remain problematic. The accumulation of p53 protein and an increased proliferative index, as measured by the expression of Ki-67 antigen, have not been used as adjuncts to the diagnosis of these lesions. Immunohistochemical stains for CEA, p53 protein, and Ki-67 antigen were performed on 31 formalin-fixed, paraffin-embedded endocervical lesions… CONTINUE READING

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