Immunohistochemical quantitation of 4-aminobiphenyl-DNA adducts and p53 nuclear overexpression in T1 bladder cancer of smokers and nonsmokers.

@article{Curigliano1996ImmunohistochemicalQO,
  title={Immunohistochemical quantitation of 4-aminobiphenyl-DNA adducts and p53 nuclear overexpression in T1 bladder cancer of smokers and nonsmokers.},
  author={Giuseppe Curigliano and Yi-jun Zhang and Li Yongzhen Wang and Giovanna Flamini and Antonio Alcini and Carlo Ratto and Mario Giustacchini and Eugenio Alcini and Achille Cittadini and Regina M. Santella},
  journal={Carcinogenesis},
  year={1996},
  volume={17 5},
  pages={
          911-6
        }
}
An immunoperoxidase method, using a monoclonal antibody which recognizes 4-aminobiphenyl (4-ABP)-DNA adducts, was developed for the detection and quantitation of DNA damage in bladder tissue and applied to stored paraffin blocks of transurethral resection specimens of 46 patients with T1 bladder cancer. Mean relative staining intensity for 4-ABP-DNA adducts was significantly higher in current smokers (275 +/- 81, n = 24) compared to nonsmokers (113 +/- 71, n = 22) (P < 0.0001). There was a… CONTINUE READING

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