Immunohistochemical p53 protein status in nonsmall cell lung cancer is a promising indicator in determining in vitro chemosensitivity to some anticancer drugs.

@article{Higashiyama1998ImmunohistochemicalPP,
  title={Immunohistochemical p53 protein status in nonsmall cell lung cancer is a promising indicator in determining in vitro chemosensitivity to some anticancer drugs.},
  author={Masahiko Higashiyama and Keiji Kodama and Hiroshi Yokouchi and K. Takami and Osamu Doi and Hisayuki Kobayashi and Keizo Tanisaka and Kazuhiko Minamigawa},
  journal={Journal of surgical oncology},
  year={1998},
  volume={68 1},
  pages={19-24}
}
BACKGROUND AND OBJECTIVES The tumor suppressor oncogene p53 abnormalities have been closely associated with resistance or sensitivity of cancer cells to some chemotherapeutic agents. We examined the association between p53 protein status in nonsmall cell lung cancer (NSCLC) and in vitro chemosensitivity to several chemotherapeutic agents. METHODS Using 146 surgically resected specimens of NSCLC, p53 status was immunohistochemically evaluated, and in vitro chemosensitivity to 5-fluorouracil (5… CONTINUE READING
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