Immunohistochemical observations on the kinetics of macrophages and myofibroblasts in rat renal interstitial fibrosis induced by cis-diamminedichloroplatinum.


It has been speculated elsewhere that growth factors produced by macrophages in response to tissue damage induce a modulation of pre-existing fibroblasts into myofibroblasts, leading to fibrosis. The development of these cells in cis-diamminedichloroplatinum (CDDP)-induced rat renal interstitial fibrosis was observed immunohistochemically. In the cortico… (More)