Immunohistochemical localization of the neural cannabinoid receptor in rat brain.

@article{Pettit1998ImmunohistochemicalLO,
  title={Immunohistochemical localization of the neural cannabinoid receptor in rat brain.},
  author={Denise A Pettit and M. P. Harrison and James M. Olson and Robert F. Spencer and Guy A. Cabral},
  journal={Journal of neuroscience research},
  year={1998},
  volume={51 3},
  pages={391-402}
}
The cannabinoid receptor family consists of two inhibitory G-protein-coupled receptors, CB1 and CB2. CB1 is distributed primarily in neural tissue, whereas CB2 is distributed predominantly in immune cells. The distribution of cannabinoid receptors in neural tissue has been demonstrated by using ligand binding autoradiography with CP55,940, a high-affinity cannabinoid receptor ligand, and in situ hybridization. However, the localization of CB1 within individual cells in the brain remains to be… CONTINUE READING