Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies.

@article{Miller2016ImmunohistochemicalLO,
  title={Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies.},
  author={Silke Miller and Hantao Liu and Karin Warfvinge and Lin Shi and Mary Dovlatyan and Cen Xu and Lars Edvinsson},
  journal={Neuroscience},
  year={2016},
  volume={328},
  pages={165-83}
}
Calcitonin gene-related peptide (CGRP) is a potent vasodilator and a neuromodulator implicated in the pathophysiology of migraine. It binds to the extracellular domains of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein (RAMP) 1 that together form the CGRP receptor. Antagonist antibodies against CGRP and its binding site at the receptor are clinically effective in preventing migraine attacks. The blood-brain barrier penetration of these antagonist antibodies is… CONTINUE READING