Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbindin D28k in human and rat pancreas.

@article{Johnson1994ImmunohistochemicalLO,
  title={Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbindin D28k in human and rat pancreas.},
  author={Julie A. Johnson and Joseph P Grande and Patrick C. Roche and Rajiv Kumar},
  journal={The American journal of physiology},
  year={1994},
  volume={267 3 Pt 1},
  pages={E356-60}
}
1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] is required for normal glucose-stimulated insulin release from pancreatic beta-cells. Biochemical characterization techniques have demonstrated the presence of the 1,25(OH)2D3 receptor (VDR) in homogenates of whole pancreas. Autoradiographic studies using radiolabeled 1,25(OH)2D3 suggest that the VDR is localized to beta-cells but are inconclusive. We used immunohistochemical techniques to stain serial sections from both human and rat pancreas with… CONTINUE READING

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