Immunohistochemical localization of somatostatin receptor sst2A in human gut and lung tissue: possible implications for physiology and carcinogenesis.

@article{Gugger2004ImmunohistochemicalLO,
  title={Immunohistochemical localization of somatostatin receptor sst2A in human gut and lung tissue: possible implications for physiology and carcinogenesis.},
  author={Mathias Gugger and Beatrice Waser and Andreas Kappeler and Agnes Schonbrunn and Jean Claude Reubi},
  journal={Annals of the New York Academy of Sciences},
  year={2004},
  volume={1014},
  pages={132-6}
}
Many neuroendocrine gastrointestinal and lung tumors express sst2A somatostatin receptors. Because the cellular location of sst2A in the corresponding non-neoplastic tissue is unknown, we searched for sst2A immuno-reactive cells and characterized their type in these tissues using a highly specific sst2A antibody (R2-88). Epithelial sst2A cells, identified as neuroendocrine, gastrin-producing cells, were found in large numbers in the antrum and the duodenum, but not in the gastric corpus. They… CONTINUE READING