Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid beta-protein (Abeta) deposition.

@article{Akiyama2001ImmunohistochemicalLO,
  title={Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid beta-protein (Abeta) deposition.},
  author={Haruhiko Akiyama and Hisatake Kondo and Kazuhiko Ikeda and Masanori Kato and Patrick L. Mcgeer},
  journal={Brain research},
  year={2001},
  volume={902 2},
  pages={277-81}
}
We investigated the immunohistochemical localization of neprilysin, a putative amyloid beta-protein (Abeta)-degrading enzyme, in postmortem human brain tissues. In the cerebral cortex, neprilysin immunoreactivity was weak, but relatively dense distribution was found in the primary somatosensory and visual cortices compared with the hippocampus and association cortices. In Alzheimer brain, neprilysin-positive dystrophic neurites occurred in senile plaques in the primary cortices, an observation… CONTINUE READING