Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain.

  title={Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain.},
  author={V Hugh Perry and D A Hume and Saimon Gordon},
  volume={15 2},
Macrophages and microglia in the developing and adult mouse brain have been identified by immunohistochemical localization of the macrophage-specific antigen F4/80 and monoclonal antibodies to the FcIgG1/2b (2.4G2) and type-three complement (Mac-1) receptors. In the adult mouse there are two classes of F4/80-positive cells; those associated with the choroid plexus, ventricles and leptomeninges and the microglia. The cells bearing Fc and complement receptors are indistinguishable, by their… CONTINUE READING
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