Immunohistochemical localization of lysyl oxidase with monoclonal antibodies.

  title={Immunohistochemical localization of lysyl oxidase with monoclonal antibodies.},
  author={Hisao Wakasaki and Akira Ooshima},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  volume={63 3},
Lysyl oxidase initiates the cross-linking of collagen and elastin by catalyzing the formation of the lysine-derived aldehyde. We cloned three hybridoma cell lines which secrete monoclonal antibodies to human lysyl oxidase. The localization of lysyl oxidase was investigated in various tissues and in cultured cells using an immunofluorescent antibody method. Antibodies showed a strong immunostaining in the aorta and dermal connective tissue suggesting a close relation to elastin and collagen… CONTINUE READING