Immunohistochemical localization of keratan sulfate and chondroitin 4- and 6-sulfate proteoglycans in subregions of the tectorial and basilar membranes.


Proteoglycans containing keratan sulfate (KSPG) and 4- and 6-sulfated epitopes of chondroitin sulfate (CSPG) were identified in distinct domains of the tectorial and basilar membranes by ultrastructural immunogold labeling with monoclonal antibodies. In the tectorial membrane (TM), the highest concentration of gold particles was present in the upper fibrous… (More)