Immunohistochemical localization of insulin-like growth factor binding protein-5 in the developing rat nervous system.

@article{Cheng1996ImmunohistochemicalLO,
  title={Immunohistochemical localization of insulin-like growth factor binding protein-5 in the developing rat nervous system.},
  author={H L Cheng and Kelly A. Sullivan and Eva L. Feldman},
  journal={Brain research. Developmental brain research},
  year={1996},
  volume={92 2},
  pages={211-8}
}
The insulin-like growth factors (IGF-I and IGF-II) are peptides with both growth-promoting and insulin-like metabolic effects. The IGFs interact with and are modulated by a group of six IGF-binding proteins (IGFBP-1 through IGFBP-6). Previous studies have characterized IGFBP-5 and IGF-I gene expression in the developing nervous system. In the current study, cellular and tissue-specific distribution of IGFBP-5 protein was examined in the developing rodent nervous system using… CONTINUE READING