Immunohistochemical localization of human protein 1 in the female prostate (Skene's gland) and the male prostate

  title={Immunohistochemical localization of human protein 1 in the female prostate (Skene's gland) and the male prostate},
  author={Milan Zavia{\vc}i{\vc} and L'udov{\'i}t Danihel and Mariana Arnoult Ru{\vz}ickov{\'a} and Jana Bla{\vz}ekov{\'a} and Yoshihisa Itoh and Ryu Okutani and Tadashi Kawai},
  journal={The Histochemical Journal},
Mouse monoclonal anti-urine protein 1 antibody and the biotin-streptavid in-peroxidase technique were used for the immunohistochemical demonstration of human protein 1 in prostatic tissue of both sexes. In the female prostate (Skene's gland), like the male prostate, high expression of human protein 1 was observed on the luminal surface and in the apical cytoplasm of secretory cells of prostatic glands, as well as on the luminal surface of the epithelium of the large ducts of the female prostate… Expand
Structure, histochemistry, and ultrastructure of the epithelium and stroma in the gerbil (Meriones unguiculatus) female prostate.
The results showed that the gerbil's female prostate shows morphological and ultrastructural homology to the human female prostate (Skene's gland), and despite being a small organ, it is a mature and physiologically active gland. Expand
Female prostate: a review about the biological repercussions of this gland in humans and rodents
It is necessary to frequently monitor the female prostate in order to prevent prostatic disorders that can endanger the quality of life of women and long-term exposure to synthetic hormones, which interferes with women's hormonal balance. Expand
Ovariectomy increases the phenotypic plasticity of the female prostate epithelium in the Mongolian gerbil (Meriones unguiculatus).
The hormonal suppression caused by ovariectomy showed that the secretory epithelial cells of the female gerbil prostate are not morphologically and functionally uniform, presenting a phenotypical plasticity according to the hormonal environment in which they operate. Expand
Morphological characterization of the female prostate (Skene's gland or paraurethral gland) of Lagostomus maximus maximus.
The anatomical and histological characteristics of the paraurethral gland in the plain viscacha, the histologic homologue to the male prostate, are described for the first time. Expand
The female prostate is a functionally active gland found in several species of mammals, including humans and rodents. In adult female gerbils, the prostate presents a paraurethral location, showingExpand
Intrauterine exposure to oestradiol promotes sex‐specific differential effects on the prostatic development of neonate gerbils
It was verified that intrauterine exposure to E2 promotes epithelial proliferation and growth of prostatic budding in females, whereas in males the prostatic fledgling shows hypomorphic growth in the VMP (Ventral Mesenchymal Pad) as well as reduced epithelialiferation. Expand
Clinical implications of the forgotten Skene's glands: A review of current literature
Abstract Introduction The clinical and pathological aspects of the Skene's glands have not been addressed in the current scientific literature. Aim To review the current literature to focus on theExpand
Histology and immunohistochemical studies of female genital tissue
This chapter considers the three anatomic structures mainly involved in sexual female arousal: the clitoris, vagina, and urethra. Expand
Beyond the G-spot: clitourethrovaginal complex anatomy in female orgasm
Knowledge of the anatomy and physiology of the CUV complex might help to avoid damage to its neural, muscular, and vascular components during urological and gynaecological surgical procedures. Expand


The adult human female prostata homologue and the male prostate gland: a comparative enzyme-histochemical study.
The observed corresponding enzymic equipment of the male andFemale prostatic tissue may provide the basis for the "histochemical concept of male and female prostate homology", which could suitably supplement the present only embryologically understood homology between the paraurethral glands and ducts so as to consider them the female prostate and the male prostate. Expand
Metastasizing adenocarcinoma of the female prostate (Skene's paraurethral glands). Histological and immunohistochemical prostate markers studies and first ultrastructural observation.
The case of a 46-year-old women with well-differentiated adenocarcinoma of the female prostate (Skene's paraurethral glands and ducts) with inguinal metastases is reported, and the first published results of electron microscopic examination of formalin fixed tissue showing the ultrastructure of female prostate carcinoma, comparable to that of the male prostate cancer. Expand
Homology between the female paraurethral (Skene's) glands and the prostate. Immunohistochemical demonstration.
This study demonstrates the homologous nature of the female paraurethral glands and the prostate and supports speculations about functional similarity. Expand
Immunohistochemical identification of prostatic acid phosphatase and prostate specific antigen in female periurethral glands.
The findings support a female homologue of the male prostate, found in 7 of 10 female urethras harvested at autopsy. Expand
Morphologic and immunologic studies of human prostatic carcinoma.
Partially purified extracts from 71 human urothelial tumors and 75 human u rothelial nontumor tissues were used as competing antigens in competition radioimmunoassay in an effort to detect the presence of one of the structural components of type-C ribonucleic acid viruses, the p30 core protein. Expand
Prostate specific antigen and prostate specific acid phosphatase in adenocarcinoma of Skene's paraurethral glands and ducts
An autopsy case of adenocarcinoma of Skene's paraurethral gland co-incident with renal cell carcinoma is described. The adenocarcinoma showed distinct prostate specific antigen and prostate specificExpand
The adult human female urethra. Enzyme-histochemical study.
The majority of the demonstrated enzymes showed an evenly distributed activity at all epithelial levels, and of the dehydrogenases priority, is to be given to succinate dehydrogenase, enabled to differentiate readily between the highly active striated muscle fibers located in the most peripheral parts of the excisions along the urethral circumference and the smooth musculature of the Urethral wall with a lower or only minimal activity. Expand
Expression of a uteroglobin-like protein in human prostate.
Uteroglobin-like protein was present in all three patients who underwent open prostatectomy and in three of the seven patients with transurethral resections, which may have implications for human male fertility. Expand
Sex-Associated Differences in Protein l Values in Urine: Immunochemical Detection of Protein l in Genital Tissues
  • S. Ishii, Y. Itoh, +4 authors Y. Asano
  • Chemistry, Medicine
  • European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies
  • 1994
Spot urine from seven normal men and seven women of reproductive age was collected in four sequentially divided fractions, and protein 1 concentration in each fraction was measured by an enzyme immunoassay using the sandwich method to analyse sex-associated differences in urinaryprotein 1 concentration. Expand
Purification of a human prostate specific antigen.
This report presents the first demonstration of the purification of a prostate-specific antigen that does not represent prostatic acid phosphatase and shows a single protein band on analytical polyacrylamide gel electrophoresis and isoelectric focusing. Expand