Immunohistochemical localization of guanine nucleotide-binding proteins in rat olfactory epithelium during development.

@article{ManiaFarnell1990ImmunohistochemicalLO,
  title={Immunohistochemical localization of guanine nucleotide-binding proteins in rat olfactory epithelium during development.},
  author={B L Mania-Farnell and Albert I. Farbman},
  journal={Brain research. Developmental brain research},
  year={1990},
  volume={51 1},
  pages={103-12}
}
It has recently been proposed that guanine nucleotide (GTP)-binding proteins (G-proteins) are involved in transducing stimuli in olfactory receptor neurons. If this is the case, G-proteins should be expressed when receptor cells first generate action potentials in response to odorants, i.e. in the rat fetus on the 16th embryonic day (E16). We have done an immunohistochemical study to determine when the alpha- and beta-subunits of the stimulatory G-protein (Gs), are expressed in developing rat… CONTINUE READING