Immunohistochemical localization of feline immunodeficiency virus using native species antibodies.

  title={Immunohistochemical localization of feline immunodeficiency virus using native species antibodies.},
  author={Arlin B. Rogers and Candace K Mathiason and Edward A. Hoover},
  journal={The American journal of pathology},
  volume={161 4},
Feline immunodeficiency virus (FIV) is the feline analog of human immunodeficiency virus and a small animal model of human acquired immune deficiency syndrome (AIDS). We sought to identify early in vivo target cells in cats infected with clade B or C FIV. In tissues, however, neither mouse monoclonal nor rabbit polyclonal antibodies suitably detected FIV because of either insensitivity or lack of specificity. We therefore developed an immunohistochemical protocol using high-antibody-titer serum… CONTINUE READING


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