Immunohistochemical localization and biological activity of the steroidogenic enzyme cytochrome P450 17alpha-hydroxylase/C17, 20-lyase (P450C17) in the frog brain and pituitary.

@article{Rego2007ImmunohistochemicalLA,
  title={Immunohistochemical localization and biological activity of the steroidogenic enzyme cytochrome P450 17alpha-hydroxylase/C17, 20-lyase (P450C17) in the frog brain and pituitary.},
  author={Jean Luc do Rego and Yves Tremblay and Van Luu-The and Emanuela Repetto and H{\'e}l{\`e}ne Castel and Mauro Vallarino and Alain B{\'e}langer and Georges Pelletier and Hubert Vaudry},
  journal={Journal of neurochemistry},
  year={2007},
  volume={100 1},
  pages={251-68}
}
It is now clearly established that the brain has the capability of synthesizing various biologically active steroids including 17-hydroxypregnenolone (17OH-Delta(5)P), 17-hydroxyprogesterone (17OH-P), dehydroepiandrosterone (DHEA) and androstenedione (Delta(4)). However, the presence, distribution and activity of cytochrome P450 17alpha-hydroxylase/C17, 20-lyase (P450(C17)), a key enzyme required for the conversion of pregnenolone (Delta(5)P) and progesterone (P) into these steroids, are poorly… CONTINUE READING

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