Immunohistochemical investigation of mid-dermal elastolysis.

  title={Immunohistochemical investigation of mid-dermal elastolysis.},
  author={Thilo Gambichler and Frank Breuckmann and Alexander Kreuter and Stefanie Boms and Peter Josef Altmeyer and Markus H F Stuecker},
  journal={Clinical and experimental dermatology},
  volume={29 2},
We report a 31-year-old Caucasian woman presenting with remarkable wrinkling on her trunk and proximal extremities. Diagnosis of mid-dermal elastolysis (MDE) was confirmed by Van Gieson's staining. Immunohistochemical investigations revealed enhanced expression of CD34+ and CD68+ cells accompanied by slightly increased expression of CD3+ and CD4+ lymphocytes in lesional skin. Furthermore an elevated cellular expression of matrix metalloproteinase (MMP)-1 and slightly increased presence of MMP… CONTINUE READING