Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc

@article{Weiler2010ImmunohistochemicalIO,
  title={Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc},
  author={Christoph Weiler and Andreas Nerlich and Rainer Schaaf and Beatrice E Bachmeier and Karin Wuertz and Norbert Boos},
  journal={European Spine Journal},
  year={2010},
  volume={19},
  pages={1761-1770}
}
The fate of notochord cells during disc development and aging is still a subject of debate. Cells with the typical notochordal morphology disappear from the disc within the first decade of life. However, the pure morphologic differentiation of notochordal from non-notochordal disc cells can be difficult, prompting the use of cellular markers. Previous reports on these notochordal cell markers only explored the occurrence in young age groups without considering changes during disc degeneration… CONTINUE READING
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