Immunohistochemical features of PrP(d) accumulation in natural and experimental goat transmissible spongiform encephalopathies.

@article{Jeffrey2006ImmunohistochemicalFO,
  title={Immunohistochemical features of PrP(d) accumulation in natural and experimental goat transmissible spongiform encephalopathies.},
  author={M Haddad Jeffrey and Stuart Martin and Lorenzo Gonz{\'a}lez and James H. Foster and Jan P. M. Langeveld and Fred G. van Zijderveld and J acques Grassi and Nora Hunter},
  journal={Journal of comparative pathology},
  year={2006},
  volume={134 2-3},
  pages={171-81}
}
Scrapie is a transmissible spongiform encephalopathy (TSE) or prion disease, which naturally affects sheep and goats. Immunohistochemical epitope mapping of abnormal PrP accumulations (PrP(d)) in brain can help in characterizing sheep TSE sources or strains and in identifying potential bovine spongiform encephalopathy (BSE) infections of sheep. Natural and experimental TSE infections of goats were examined to determine whether the epitope mapping approach could also be applied to aid… CONTINUE READING

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