Immunohistochemical expression of retinoblastoma and phospho-retinoblastoma protein in lung sheep exposed to fluoro-edenite fibers

@article{Musumeci2010ImmunohistochemicalEO,
  title={Immunohistochemical expression of retinoblastoma and phospho-retinoblastoma protein in lung sheep exposed to fluoro-edenite fibers},
  author={Giuseppe Musumeci and Carla Di Loreto and Venera Cardile and Maria Luisa Carnazza and Giuseppina Martinez},
  journal={Anatomical Science International},
  year={2010},
  volume={85},
  pages={74-78}
}
The immunohistochemical expression of retinoblastoma protein (Rb) and its phosphorylated form (pRb) was investigated in an in vivo sheep model, i.e., lung tissue exposed to asbestos-like fibers. Rb is a phosphoprotein with a central role in controlling the cell cycle, cell growth regulation, differentiation, and apoptosis. pRb functions as a checkpoint in the G1 phase, favoring cell growth, while the hypophosphorylated form (Rb) not only promotes cell-cycle arrest and a return to the G1 phase… CONTINUE READING
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